Ambiance, as much as food, can play a huge role when it comes to whether we return to a restaurant again and again. If we’re comfortable and enjoy the entire dining experience, we’re more likely to come back. Chances are, when you visit The Depot Café, a train depot restaurant in Missouri, you’ll follow in the footsteps of other guests and become a regular – especially if you live nearby. See if you agree that it’s one of the best restaurants in Missouri.

Indulge in a hearty meal and a piece of rich history when you visit The Depot Café in Fredericktown, a popular restaurant tucked in a former train depot.
Teri Shafer/Google Reviews
One glance at the Depot Bar and Grill menu is sure to get your mouth watering in anticipation of a delicious meal.
Before it became an adorable restaurant that predominately dishes up made-from-scratch meals, the historic building served as the Missouri Pacific Railroad Station. Today, the restaurant gives off a cozy vibe.
Facebook/The Depot Café
If you've looked up "depot restaurant near me" and you're in Missouri, this is probably the one for which you were looking.
Diners give the former train depot glowing marks in The Depot Cafe reviews for its comfortable, friendly atmosphere, and attentive service, and when it comes to the food? It too, garners, praise. However, you’ll probably want to taste for yourself.
Facebook/The Depot Café
Of all the restaurants in Missouri, the Depot Cafe might be one of the most unique.
The Depot Café serves lunch and dinner, offering a menu brimming with deliciousness – from appetizers to homemade soups and chili.
Facebook/The Depot Café
Often called the Depot Restaurant, this Missouri eatery is known for serving its food fresh and hot. Go hungry because you'll want to savor every bite.

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When you’re craving an old-fashioned sandwich, you’ll find an impressive selection at The Depot Café. Double grilled cheese, grilled ham and cheese, and Rueben are just a few of your choices.
Facebook/The Depot Café
Don't worry if you're in the mood for something a little bit lighter. How about ordering a bowl of soup or chili and pairing it with a salad, like the tossed or the Caesar? The Depot Cafe also serves entree salads.
If you’re really hungry, take a peek at the dinner menu that offers a little bit of everything, from classic pork chops to roasted garlic chicken breast.
Facebook/The Depot Café
All dinner entrees come with soup or salad and potatoes.
A juicy steak sometimes hits the spot, and you can choose from a few favorites, including the impressive one-pound ribeye steak. If you don’t think you can finish it all, you can share it or take the leftovers home in a doggy bag.
Facebook/The Depot Café
In the mood for something unique? Try the steak and cheese ravioli. The Depot Cafe also serves a scrumptious selection of seafood dishes.
The little ones have their own menu that features such kid-approved favorites as hot dogs, hamburger with pickles, and grilled cheese.
Facebook/The Depot Café
View days, hours, and more on the The Depot Cafe Facebook page.
Facebook/The Depot Café

Have you been to The Depot Café, one of the best restaurants in Missouri? What’s the verdict? Share your experience in the comments! If you haven’t dined at this train depot restaurant in MO before, why not book a room at Madison Inn Lodge and spend some time exploring the area after your meal?

For a whimsical experience and a delicious meal, head over to Fritz’s Railroad Restaurant, with two locations in Kansas City, Missouri, and one in Shawnee, Kansas.

OnlyInYourState may earn compensation through affiliate links in this article. As an Amazon Associate, we earn from qualifying purchases.

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Train Depot Restaurant & Related Info

Beth Price-Williams | April 24, 2023

What are some of the best restaurants in Missouri?

The Depot Café certainly tops the list of the most unique restaurants in Missouri. However, it’s just one of the best restaurants in Missouri. Some others include:

  • Lambert’s in Sikeston promises a one-of-a-kind experience where you can catch your own dinner rolls. Waitstaff tosses the dinner rolls to diners, one of the signature traits of this Missouri restaurant.
  • Kehde’s BBQ in Sedalia offers another unique dining experience in Missouri. Tucked in a former train car, it dishes up some of Missouri’s best barbecue. Be sure to try their famous posh potatoes.
  • The White Rose Café in Union has been a favorite for nearly eight decades. It’s known for its all-day breakfast.
  • Blueberry Hill in St. Louis is perhaps best known for performances by Chuck Berry. The legendary singer performed at this Missouri restaurant on the third Wednesday of each month from 1996 until his 88th birthday in 2004.

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Featured Addresses
The Depot Cafe, 406 Villar St, Fredericktown, MO 63645, USA