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There are many beautiful B&Bs throughout Missouri. However, few offer dining, shopping, wine tasting, and history all under one roof. At Twelve Mile Creek Emporium, Wine Cottage, and B&B you can experience all of this and more. This historic inn was once a Civil War hospital, and its underground tunnels were used to help former slaves escape to the north. You’ll love the history and the hospitality. Keep reading to find out how you can stay in this beautiful B&B.

The large yellow house that sits proudly on Main St. in Caledonia has an amazing past. Twelve Mile Creek Emporium, Wine Cottage, and B&B was once know by locals as the Ramsey House and is now a National Historic Landmark.
Twelve Mile Creek Emporium, Wine Cottage, and B&B/Facebook
During the Civil War the inn became a hospital for both Union and Confederate solders. However, the most interesting history sits below the house. The tunnels that connected the large home to two small adjacent dwellings also helped former slaves escape on the Underground Railroad.
Twelve Mile Creek Emporium, Wine Cottage, and B&B/Facebook
Today, one of the most popular rooms at Twelve Mile Creek is the former quarantine room. This lovely room originally was not quite as comfortable.
Twelve Mile Creek Emporium, Wine Cottage, and B&B/Facebook
While the inn operated as a hospital, the room on the third floor became the quarantine room for solders who had communicable diseases. The metal door was installed with a window to pass food and water though. The door remains a part of the room to this day.
Twelve Mile Creek Emporium, Wine Cottage, and B&B/Facebook

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In addition to providing lodging, Twelve Mile Creek serves great food. They have weekend specials, but feature soups, salads, and sandwiches on their fixed menu.
Twelve Mile Creek Emporium, Wine Cottage, and B&B/Facebook
After a bite to eat, check out their collection of home decor, western ware, children's clothing, and more. They get new items in all the time!
Twelve Mile Creek Emporium, Wine Cottage, and B&B/Facebook
Relax out on their patio with a class of local craft beer or wine. On most warm weekends you can also catch a band out back too!
Twelve Mile Creek Emporium, Wine Cottage, and B&B/Facebook
Spend the day or the weekend at Twelve Mile Creek and enjoy everything this historic inn has to offer.
Twelve Mile Creek Emporium, Wine Cottage, and B&B/Facebook
Find the lovely B&B at 128 S State Highway 21, Caledonia. For more information or to make reservations, visit their website here. Regular store and restaurant hours are Friday and Saturday from 1 a.m. until 8 p.m., and Sunday from 11 a.m. until 6 p.m.

Looking for great B&B’s across Missouri? Check out an earlier article where we featured 14 of the best B&B’s in the Show Me State.

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